Value of free PSA/total PSA ratio in the therapeutic decision in the context of a single positive prostatic biopsy.

Objectives: Study of the value of the free PSA/total PSA ratio in the thera peutic decision concerning prostatic adenocarcinoma, in the case of a singl e positive biopsy. Material and Methods: The free PSA/total PAS ratio was calculated on serum samples derived from 37 patients with clinically localized prostatic carcin oma and only one positive biopsy, in whom radical prostatectomy was perform ed. Results: The free PSA/total PSA ratio appeared to be independent of patholo gical stage and histological prognostic criteria (grade and score, degree o f capsular effraction). Conclusion: In the case of a single positive biopsy, calculation of the fre e PSA/total PSA ratio does not appear to provide any decisional criteria in favour of radical prostatectomy.