We discuss instantons in dimensions higher than four. A generalized self-du
al or anti-self-dual instanton equation in n-dimensions can be defined in t
erms of a closed (n - 4) form Ohm and it was recently employed as a topolog
ical gauge fixing condition in higher dimensional generalizations of cohomo
logical Yang-Mills theory. When Ohm is a calibration which is naturally int
roduced on the manifold of special holonomy, we argue that higher dimension
al instanton may be locally characterized as a family of four dimensional i
nstantons over a supersymmetric (n - 4) cycle Sigma with respect to the cal
ibration Ohm. This is an instanton configuration on the total space of the
normal bundle N(Sigma) of the submanifold Sigma and regarded as a natural g
eneralization of point-like instanton in four dimensions that plays a disti
nguished role in a compactification of instanton moduli space.