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Genome rearrangements are responsible for the variability observed at the e
nds of the chromosome among Streptomyces species. The characterization of m
utators, which are stimulated for genome plasticity, and of mutants produce
d at different stages of development support the idea that genome instabili
ty is developmentally modulated. (C) 1999 Editions scientifiques et medical
es Elsevier SAS.