Anti neutrophil cytoplasmic antibody (ANCA) positive crescentic glomerulonephritis in children. Report of two cases

Anti neutrophil cytoplasmic antibodies are associated to vasculitis and cre scentic glomerulonephritis in adults. However, this association has been se ldom reported in children. We report two girls aged 12 and 15 years old wit h ANCA + glomerulonephritis. Both were subjected to a percutaneous kidney b iopsy. One girl had to enter a chronic hemodialysis program. The other pati ent recovered her renal function and after 12 months of treatment with ster oids and cyclophosphamide microscopic hematuria and proteinuria persist but with normal kidney function. ANCA should be measured in children with vasc ulitis and glomerulonephritis.