Clinical renal involvement in sarcoidosis (report of nine cases).

Purpose. - Clinical renal outbreaks occurring in the course of sarcoidosis are polymorphous Methods. - Nine patients presenting with sarcoidosis were followed up for 1 8 years. Results. - Five patients presented with chronic interstitial nephritis. Ren al failure accompanying granuloma was also present in three of them Cortico therapy allowed rapid improvement in renal function in three patients In tw o other cases, late treatment prevented recovery and led to endstage renal failure in one case. In another case persistent hypercalciuria was responsi ble for bilateral nephrolithiasis further treated via extracorporeal lithot rity. One case of mesangial glomerulonephritis and two morbid associations (retroperitoneal fibrosis and Henoch-Schonlein purpura) were observed. Conclusion, - Interstitial nephritis is still a severe clinical renal outbr eak. Corticotherapy must be prescribed early to avoid renal failure. Calciu m metabolism disorders are frequent and often combined with interstitial ne phritis. Hypercalcemia can often and rapidly be improved via corticotherapy , white monitoring of hypercalciuria proves to be more difficult. Membranou s glomerulonephritis is still the most frequently reported glomerular lesio n. (C) 1999 Elsevier, Paris.