Neuroprotective therapy

Neuroprotective therapy for stroke remains unproven despite its ability to substantially reduce injury in animal stroke models. Based on an understand ing of the cascade of biochemical events that follow interruption of blood flow to the brain, various, neuroprotective drugs have been tested in clini cal studies, but none have been shown to improve clinical outcome. Progress depends on designing our clinical trials to better simulate the experiment al conditions under which these drugs have been found to be effective.