Despite the fact that most women with metastatic breast cancer eventually s
uccumb to their disease, chemotherapy, hormonal therapy, radiotherapy, and
limited surgery are effective treatment modalities to achieve palliation, i
mprove quality-of-life, and significantly prolong life. Appropriate therapy
is developed based on the patient's age, disease-free interval, hormone re
ceptor status, and extent of disease. Treatment should be tailored specific
ally to each patient, taking into account the patient's goals, underlying m
edical conditions, and overall performance status-especially endpoints in t
herapy and ability to tolerate a particular therapy. Carefully sequenced th
erapy often results in prolonged survival, in contrast to that for most sol
id tumors.