Genetic testing for breast cancer predisposition

The recent identification of the BRCA1 and BRCA2 genes has improved our und erstanding of the association between breast and ovarian cancers in certain families. Carriers of predisposing germline mutations must decide on diffe rent options for management, including close follow-up or prophylactic surg ery. Further studies are needed to elucidate the optimal management of thes e patients and to identify the factors that modify their risk for developin g breast cancer. Finally, we must work to prevent any form of discriminatio n against those who, following, genetic testing, are found to be at increas ed risk for breast cancer.