Typical atrial flutter in humans is the consequence of a stable macro-reent
rant circuit produced by the unique right atrial architecture providing ana
tomic barriers and functional blocks to conduction. Mapping studies have in
dicated that the so-called isthmus between the inferior aspect of the tricu
spid annulus and the ostium of the inferior caval vein is a critical zone f
or maintenance of atrial flutter. An anatomically guided approach with plac
ement of a transmural and contiguous lesion line throughout the isthmus has
established as curative treatment of typical atrial flutter. Electrophysic
al criteria indicating complete bidirectional isthmus conduction block afte
r ablation proved to be superior with respect to redurrences of atrial flut
ter compared with the noninducibility criterion. The gold standard for prov
e of complete conduction block is the recording of double potentials along
the entire isthmus ablation line. Recently, it proved possible to reduce th
e period of fluoroscopy during isthmus ablation by using electro-anatomical
mapping.