Pharmacokinetics of florfenicol after treatment of pigs with single oral or intramuscular doses or with medicated feed for three days

Citation
J. Voorspoels et al., Pharmacokinetics of florfenicol after treatment of pigs with single oral or intramuscular doses or with medicated feed for three days, VET REC, 145(14), 1999, pp. 397-399
Citations number
13
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY RECORD
ISSN journal
00424900 → ACNP
Volume
145
Issue
14
Year of publication
1999
Pages
397 - 399
Database
ISI
SICI code
0042-4900(19991002)145:14<397:POFATO>2.0.ZU;2-M
Abstract
The pharmacokinetics of florfenicol, a structural analogue of thiamphenicol , were studied in six pigs after single oral and intramuscular doses of 15 mg/kg bodyweight, and after feeding them with medicated feed containing 250 mg/kg for three days, a concentration which provided approximately the sam e dose rate of the drug. The oral doses contained a specially prepared pell eted formulation of the drug. The bioavailability of the drug was similar f or the oral and intramuscular doses. Florfenicol was absorbed rapidly from the feed and its concentration in plasma remained between 2 and 6 mu g/ml - above the minimum inhibitory concentration values for common pig pathogens - during the three days.