J. Voorspoels et al., Pharmacokinetics of florfenicol after treatment of pigs with single oral or intramuscular doses or with medicated feed for three days, VET REC, 145(14), 1999, pp. 397-399
The pharmacokinetics of florfenicol, a structural analogue of thiamphenicol
, were studied in six pigs after single oral and intramuscular doses of 15
mg/kg bodyweight, and after feeding them with medicated feed containing 250
mg/kg for three days, a concentration which provided approximately the sam
e dose rate of the drug. The oral doses contained a specially prepared pell
eted formulation of the drug. The bioavailability of the drug was similar f
or the oral and intramuscular doses. Florfenicol was absorbed rapidly from
the feed and its concentration in plasma remained between 2 and 6 mu g/ml -
above the minimum inhibitory concentration values for common pig pathogens
- during the three days.