Circadian intraocular pressure variation with beta-blockers

Purpose: To investigate circadian intraocular pressure variation in patient s treated with topical beta-blockers as monotherapy, Method: Circadian IOP curves were measured on 25 patients (J7 eyes) treated with topical beta-blockers. IOP was recorded 4 times during the day and tw ice at night. All IOP measurements were taken using a non-contact tonometer , Results: IOP at night mas significantly higher than IOP during the day Thir ty-four percent exhibited an increase in IOP of more than 5 mmHg at night, and 15% exhibited an increase of 10-18 mmHg at night. The median range of c ircadian IOP variation was 7 mmHg, Determined separately by day, the range of IOP variation was 4 mmHg, Conclusion: Patients treated with beta-blockers as monotherapy may experien ce greater variations in IOP than can be detected by conventional daytime I OP measurements.