Background: Neuropathological studies use the presence of mammillary body (
MB) pathology as a cardinal, diagnostic feature of Wernicke's encephalopath
y (WE) in neuropsychiatric diseases, most notably alcoholism. Although Kors
akoffs Syndrome (KS), which is marked behaviorally by dense global amnesia,
is a typical sequela of WE, it remains controversial whether these two con
ditions necessarily co-occur and whether MB pathology is therefore a diagno
stic requisite for KS.
Methods: We investigated these issues by examining, in vivo, 24 nonamnesic
alcoholics (ALC), 5 amnesic alcoholics (KS), and 51 normal controls with th
ree-dimensional MRI and memory testing. MB volume was determined from succe
ssive, 1 mm thick slices.
Results: The ALC group had significantly smaller MB volumes bilaterally (me
an = 54.5 +/- 22.0 mm(3)) than controls (mean = 66.3 +/- 17.1 mm(3)), and t
he KS group had even smaller MB volumes than the ALC group (mean = 20.7 +/-
14.8 mm(3)). Only 2 ALC patients met historical clinical criteria for past
WE, and their MB volumes were well within range of the remaining 22 ALC pa
tients. Although all five KS patients met historical clinical criteria for
WE, three KS did not have accompanying dementia and had the same degree of
MB volume loss as the ALC; the remaining two KS had accompanying dementia a
nd MB volumes half the volume of the ALC group and of KS patients without d
ementia.
Conclusions: These findings provide volumetric in vivo evidence that: (1) M
B volume deficits do occur in alcoholics without amnesia, although these de
ficits are not present in all such alcoholics; (2) greater MB volume defici
ts are present in alcoholics with clinically detectable amnesia or dementia
; (3) MB shrinkage is related to severity of cognitive and memory dysfuncti
on, which suggests a continuum of MB pathology in chronic alcoholism to KS;
and (4) the presence of WE in all of the KS patients and in the two ALC pa
tients with the greatest long-term declarative memory deficit supports the
possibility of an additional and unique pathology distinguishing nonamnesic
and amnesic alcoholism.