Quantitative determination of miconazole in creams by second order derivative spectrophotometry

Authors
Goger, NG Gokcen, L
Citation
Ng. Goger et L. Gokcen, Quantitative determination of miconazole in creams by second order derivative spectrophotometry, ANAL LETTER, 32(13), 1999, pp. 2595-2602
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICAL LETTERS
ISSN journal
00032719 → ACNP
Volume
32
Issue
13
Year of publication
1999
Pages
2595 - 2602
Database
ISI
SICI code
0003-2719(1999)32:13<2595:QDOMIC>2.0.ZU;2-P
Abstract
A derivative spectrophotometry was developed to determine miconazole in cre am formulations that contain benzoic acid as preservative. The procedure wa s based on the linear relationship in the range 100-500 mu g ml(-1) between the drug concentration and the second derivative amplitudes at 276 nm. Res ults of the recovery experiments performed on various amounts of benzoic ac id and of the determination of miconazole in cream confirmed the applicabil ity of the proposed method to complex formulations.