Ticlopidine-induced lymphocytic colitis.

Lymphocytic colitis is a clinico-pathological syndrome characterized by chr onic diarrhea, normal endoscopy, diffuse colonic mucosal inflammatory chang es. Collagenous colitis is defined by a thickening of the collagen plate. T he etiology is unknown but immune disorders have been frequently associated with it and it has been linked with the taking of certain drugs such as no nsteroid anti-inflammatory drugs or veinotonics. We are reporting a case of microscopic colitis associating both lymphocytic and collagenous colitis, wich induced chronic diarrhea in a 65-year-old man, It appeared after he ha d taken ticlopidine, Diarrhea stopped after he had discontinuated ticlopidi ne, and recurred after he resumed taking the drug. Histological damages fro m lymphocytic colitis improved six month after he had stopped taking ticlop idine, Chronic diarrhea induced by ticlopidine might be caused by lymphocyt ic colitis.