Synthesis and antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclobutane ring Part 1: Guanosine analogues

The new carbocyclic nucleosides were prepared by constructing a guanine (co mpounds 3, 5) or 8-azaguanine (compounds 4, 6, and 7) base on the amino gro up of (1'S, 3'R)-3-(3'-amino-2', 2'-di-methylcyclobutyl) propan-1-ol (8), a nd their activities against a variety of viruses and tumor cell lines were determined. Only compounds 3 and 7 showed a detectable activity at subtoxic concentrations against some viruses tested.