Studies on the synthesis and properties of new PNA analogs consisting of L- and D-lysine backbones

Authors
Zhang, LG Min, JM Zhang, LH
Citation
Lg. Zhang et al., Studies on the synthesis and properties of new PNA analogs consisting of L- and D-lysine backbones, BIOORG MED, 9(20), 1999, pp. 2903-2908
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
2903 - 2908
Database
ISI
SICI code
0960-894X(19991018)9:20<2903:SOTSAP>2.0.ZU;2-T
Abstract
Homopentamers of PNA consisting of L- and D-lysine were synthesized. It was found that the intramolecular hydrogen bonding has no significant influenc e on intermolecular interaction. These pentamers show a tendency to form co mplex with polyA in tris(pH 8.0) solution. The L-conformer has more potenti al than D-isomer. (C) 1999 Elsevier Science Ltd. All rights reserved.