Stabilization of microtubules by combretastatin D derivatives

Authors
Couladouros, EA Li, TH Moutsos, VI Pitsinos, EN Soufli, IC
Citation
Ea. Couladouros et al., Stabilization of microtubules by combretastatin D derivatives, BIOORG MED, 9(20), 1999, pp. 2927-2928
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
2927 - 2928
Database
ISI
SICI code
0960-894X(19991018)9:20<2927:SOMBCD>2.0.ZU;2-0
Abstract
The effect of five derivatives of Combretastatin D on tubulin polymerizatio n was investigated. All of them were found to stabilize microtubules to var ious degrees. The derivatives bearing polar substituents were found to be t he most active. (C) 1999 Elsevier Science Ltd. All rights reserved.