Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro.

Authors
Larget, R Lockhart, B Pfeiffer, B Neudorffer, A Fleury, MB Largeron, M
Citation
R. Larget et al., Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro., BIOORG MED, 9(20), 1999, pp. 2929-2934
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
2929 - 2934
Database
ISI
SICI code
0960-894X(19991018)9:20<2929:SONODA>2.0.ZU;2-3
Abstract
A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compound s exhibited a potent antioxidant activity close to that of standard alpha-t ocopherol. (C) 1999 Elsevier Science Ltd. All rights reserved.