Inhibition of E-coli growth by fullerene derivatives and inhibition mechanism

Authors
Mashino, T Okuda, K Hirota, T Hirobe, M Nagano, T Mochizuki, M
Citation
T. Mashino et al., Inhibition of E-coli growth by fullerene derivatives and inhibition mechanism, BIOORG MED, 9(20), 1999, pp. 2959-2962
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
2959 - 2962
Database
ISI
SICI code
0960-894X(19991018)9:20<2959:IOEGBF>2.0.ZU;2-O
Abstract
Cationic ammonium fullerene derivatives (C-60-bis(N, N-dimethylpyrrolidiniu m iodide) and C-60-bis(N-methylpiperazinium iodide)) suppressed E. coli gro wth, whereas an anionic derivative (C-60-dimalonic acid) did not. Both cati onic derivatives inhibited E. coli dioxygen consumption. Inhibition of ener gy metabolism is concluded to be a mechanism of the growth inhibition effec t of fullerene derivatives. (C) 1999 Elsevier Science Ltd. All rights reser ved.