The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems

Authors
Laub, JB Greenlee, ML DiNinno, F Huber, JL Sundelof, JG
Citation
Jb. Laub et al., The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems, BIOORG MED, 9(20), 1999, pp. 2973-2976
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
2973 - 2976
Database
ISI
SICI code
0960-894X(19991018)9:20<2973:TSAAAO>2.0.ZU;2-Y
Abstract
A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent a ctivity against MRSA has been synthesized via a Stille cross-coupling react ion. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a consequence of the positively charged amidinium subst ituent. (C) 1999 Elsevier Science Ltd. All rights reserved.