Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70

Authors
Vu, CB Corpuz, EG Pradeepan, SG Violette, S Bartlett, C Sawyer, TK
Citation
Cb. Vu et al., Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70, BIOORG MED, 9(20), 1999, pp. 3009-3014
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
3009 - 3014
Database
ISI
SICI code
0960-894X(19991018)9:20<3009:NSIOTT>2.0.ZU;2-E
Abstract
The synthesis of a series of 1,2,4-oxadiazole analogs is discussed along wi th their ZAP-70 SH2 inhibitory activity. The tyrosine moiety in the origina l series has been replaced with nonpeptidic functional groups without a sub stantial loss of binding affinity. (C) 1999 Elsevier Science Ltd. All right s reserved.