Citation
P. Mayer et al., A new efficient synthesis of efaroxan, BIOORG MED, 9(20), 1999, pp. 3021-3022
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
3021 - 3022
Database
ISI
SICI code
0960-894X(19991018)9:20<3021:ANESOE>2.0.ZU;2-C
Abstract
The key step of the synthesis of efaroxan was the dihydrobenzofuran ring fo
rmation involving an intramolecular cyclization of the tertiary alcohol int
ermediate with the fluoroaromatic moiety in basic medium. This carbinol was
prepared according to two routes, either from reaction of a benzyl Grignar
d reagent with an alpha-ketoester, or from a Darzens condensation. (C) 1999
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