Partition coefficients (free ligands and their iron(III) complexes) and lipophilic behavior of new abiotic chelators. Correlation to biological activity

Authors
Thomas, F Baret, P Imbert, D Pierre, JL Serratrice, G
Citation
F. Thomas et al., Partition coefficients (free ligands and their iron(III) complexes) and lipophilic behavior of new abiotic chelators. Correlation to biological activity, BIOORG MED, 9(20), 1999, pp. 3035-3040
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
3035 - 3040
Database
ISI
SICI code
0960-894X(19991018)9:20<3035:PC(LAT>2.0.ZU;2-S
Abstract
Partition coefficients between n-octanol and water have been measured for t en tripodal ligands with catecholate or hydroxyquinolinate or pyridinopheno late chelating subunits and for their iron(III) complexes. The abilities of the ligands to cross an octanol phase and to extract ferric ion from its E DTA complex in an aqueous phase are studied. Correlation with biological pr operties are discussed, (C) 1999 Elsevier Science Ltd. All rights reserved.