Jumping translocations involving 11q in a non-Hodgkin lymphoma

This paper presents the results of a cytogenetic analysis in an 11-year-old boy with non-Hodgkin lymphoma. The investigation was performed on slides o btained from short-term culture of lymph node cells. The analyses revealed an abnormal clone with loss of the Y, gain of an X chromosome, t(3;22), tri somy 11, and three cytogenetically-related subclones with jumping transloca tions involving 11q13 as the common breakpoint region. This region is an un usual site of chromosome breakage in jumping translocations, and has not be en reported thus far. Contrary to most published reports, the jumping trans location in our patient is associated with long survival. (C) Elsevier Scie nce Inc., 1999. All rights reserved.