Translocation (12;17)(q13;q23) in de novo acute myeloid leukemia with trilineage myelodysplasia

12q13 abnormalities have been reported to be associated with a variety of b enign and malignant solid tumors. Recently, they have been shown to be a no nrandom karyotypic change in acute myeloid leukemia. We report a case of de novo acute myeloid leukemia with trilineage myelodysplasia showing t(12;17 )(q13;q23) as the sole chromosomal abnormality. A review of the literature indicates that 12q13 translocation in acute myeloid leukemia is often assoc iated with concomitant dysmyelopoietic changes. There is also evidence to s uggest that 12q13 translocation occurs more frequently in acute myeloid leu kemia with a prior history of mutagenic exposure or karyotypic indicators o f secondary leukemia. (C) Elsevier Science Inc., 1999. All rights reserved.