Monoamine oxidase inhibitory naphthoquinone and/or naphthalene dimers fromLemuni Hitam (Diospyros sp.), a Malaysian herbal medicine

Authors
Okuyama, E Homma, M Satoh, Y Fujimoto, H Ishibashi, M Yamazaki, M Satake, M Ghazali, AB
Citation
E. Okuyama et al., Monoamine oxidase inhibitory naphthoquinone and/or naphthalene dimers fromLemuni Hitam (Diospyros sp.), a Malaysian herbal medicine, CHEM PHARM, 47(10), 1999, pp. 1473-1476
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
10
Year of publication
1999
Pages
1473 - 1476
Database
ISI
SICI code
0009-2363(199910)47:10<1473:MOINAN>2.0.ZU;2-0
Abstract
From the extract of a Malaysian herbal medicine, Lemuni Hitam (Diospyros sp ,), which exhibited monoamine oxidase (MAO) inhibition, three new naphthoqu inone and/or naphthalene dimers (lemuninols AC, 1-3) were isolated together with 4,6-dihydroxy-5-methoxy-2-methyl-naphthalene (8) and six known monome rs (4-7, 9 and 10). The structures were determined by spectroscopic methods including 2D-NMR techniques, Among them, lemuninol A showed 45% inhibition of MAO (mouse liver) at 5.0x10(-6) g/ml, and lemuninols B and C and a naph thoquinone (9) indicated weak activity. Some related quinones were also tes ted for their MAO inhibitory activities.