Coronary artery disease in potential lung transplant recipients > 50 yearsold - The role of coronary intervention

Study objectives: To review the experience of the Alfred Hospital in the sy stematic assessment of coronary artery disease (CAD) using coronary angiogr aphy (CA), and the subsequent management of CAD, in potential lung transpla nt recipients. Design: Retrospective study. Setting: The Alfred Hospital Lung and Heart Transplant Service. Patients: CAD risk factors were sought in potential recipients of lung tran splantation (LTx) who were > 50 years old, including a history of smoking, male gender, hypertension, diabetes, hypercholesterolemia, angina, and a fa mily history of CAD, When feasible, and in the presence of more than one ca rdiac risk factor, CA was performed. Results: From 243 referral patients who were > 50 years old, 97 were listed for LTx, and 77 underwent LTx. Four patients were refused LTx on the basis of CAD. Of 101 patients undergoing a detailed cardiac assessment for LTx, 83 had smoked, 56 were male, 48 had hypercholesterolemia, 22 had hypertensi on, 4 had diabetes, and 3 had a history consistent with angina, Eighty-five patients underwent CA. In 32 cases, CA revealed CAD, and half of these cas es were significant stenoses, Eight patients who were assessed required int ervention. Five patients of this group have been transplanted; of these, th ree patients underwent coronary artery grafting at the time of LTx, and two patients underwent preoperative angioplasty or stenting. Only one of these five patients died < 90 days postoperatively, Conclusion: Significant CAD is a common finding in older patients who are p resenting for LTx. Coronary revascularization for severe large vessel steno ses can allow safe LTx, CAD risk factors may predict who should undergo CA, but fill-ther studies of clinical and noninvasive assessments of CAD are n eeded if CA is to be safely avoided in patients at low risk of CAD.