AN INTERACTIVE WEB SITE PROVIDING MAJOR HISTOCOMPATIBILITY LIGAND PREDICTIONS - APPLICATION TO HIV RESEARCH

Authors
DEGROOT AS JESDALE BM SZU E SCHAFER JR CHICZ RM DEOCAMPO G
Citation
As. Degroot et al., AN INTERACTIVE WEB SITE PROVIDING MAJOR HISTOCOMPATIBILITY LIGAND PREDICTIONS - APPLICATION TO HIV RESEARCH, AIDS research and human retroviruses, 13(7), 1997, pp. 529-531
Citations number
5
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
AIDS research and human retroviruses → ACNP
ISSN journal
08892229
Volume
13
Issue
7
Year of publication
1997
Pages
529 - 531
Database
ISI
SICI code
0889-2229(1997)13:7<529:AIWSPM>2.0.ZU;2-S
Abstract
EpiMatrix/HIV, a tool that is currently available on the World Wide We b, enables researchers to screen HIV proteins for potential MHC ligand s. We have performed a comparison of EpiMatrix predictions to 158 publ ished allotype-specific HLA-associated peptides (MHC ligands) derived from 133 proteins. The top 10 ranked EpiMatrix predictions for each of the 158 HLA allotype-protein pairs were selected for comparison with these published ligands, EpiMatrix correctly identified 134 of 158 pub lished ligands (85%). The algorithm is now available for use by the HI V research community at the URL http://www.EpiMatrix.com/HIV.