The biological cost of antibiotic resistance

Authors
Andersson, DI Levin, BR
Citation
Di. Andersson et Br. Levin, The biological cost of antibiotic resistance, CURR OPIN M, 2(5), 1999, pp. 489-493
Citations number
37
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY
ISSN journal
13695274 → ACNP
Volume
2
Issue
5
Year of publication
1999
Pages
489 - 493
Database
ISI
SICI code
1369-5274(199910)2:5<489:TBCOAR>2.0.ZU;2-5
Abstract
The frequency and rates of ascent and dissemination of antibiotic resistanc e in bacterial populations are anticipated to be directly related to the vo lume of antibiotic use and inversely related to the cost that resistance im poses on the fitness of bacteria. The data available from recent laboratory studies suggest that most, but not all, resistance-determining mutations a nd accessory elements engender some fitness cost, but those costs are likel y to be ameliorated by subsequent evolution.