Lineages and transcription factors in the specification of vertebrate primary sensory neurons

Authors
Anderson, DJ
Citation
Dj. Anderson, Lineages and transcription factors in the specification of vertebrate primary sensory neurons, CUR OP NEUR, 9(5), 1999, pp. 517-524
Citations number
81
Categorie Soggetti
Neurosciences & Behavoir
Journal title
CURRENT OPINION IN NEUROBIOLOGY
ISSN journal
09594388 → ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
517 - 524
Database
ISI
SICI code
0959-4388(199910)9:5<517:LATFIT>2.0.ZU;2-C
Abstract
Recent advances have indentified some of the key transcriptional regulators of mammalian genes, the neurogenins. Neurogenins 1 and 2 appear to control distinct sublineages for different classes of sensory neurons, including a 'pioneer' lineage for proprioceptors specified early in neural crest migra tion. Neurogenins act via a cascade of downstream transcriptional regulator s, some of which have been identified.