SAPHO syndrome: Report of three cases and review of the literature

SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) is an acron ym that describes a seronegative syndrome of bone and joint lesions, freque ntly localized to the anterior chest wail, associated with variable dermato logic manifestations. Dermatologists should be aware of this entity as earl y diagnosis can prevent unnecessary surgery and avoid prolonged ineffective antibiotic therapy. We report three new cases and review the literature.