Mg. Fontana et al., Inhibitory effect of a gastrin receptor antagonist, CR2945, on 1,2-dimethylhydrazine-induced colorectal cancer in mice, EUR SURG RE, 31(5), 1999, pp. 406-411
This study tested the effect of a new gastrin receptor antagonist, CR2945,
on colorectal cancer induced by 1,2-dimethylhydrazine (DMH) in mice. 75 CD1
male mice were divided into 3 groups: group 1 received 1 weekly injection
of 20 mg/kg of DMH and 2 daily intraperitoneal injections of 0.5 mi of NaCl
0.9% solution for 5 weeks; groups 2 and 3 received the same weekly dose of
DMH and 2 daily injections of CR2945 at the respective doses of 2.5 and 7.
5 mg/kg for 5 weeks. The animals were sacrificed 25 and 38 weeks after the
first injection. No tumours were found at the 25th week. A lower cancer fre
quency (4%) was observed in treated animals compared to controls (37.4%) at
the 38th week (p = 0.002). These data show that CR2945 could prevent chemi
cally induced colon cancer development in mice.