p-chloroamphetamine (PCA) suppresses ingestive behavior in male rats

Ingestive behavior was activated in male rats by intraoral intake and intak e from a bottle of l-M solution of sucrose. Intraperitoneal injection of p- chloroamphetamine (PCA), releasing central 5-hydroxytryptamine (5-HT) from serotonergic nerve terminals, inhibited ingestion of the sucrose solution. Significant inhibition of sucrose intake by PCA was observed at 1.25 and 2. 5 mg/kg dose in a bottle intake test, and at 5.0 mg/kg dose in an intraoral intake test. These findings suggested that 1.25 and 5.0 mg/kg of PCA suppr essed appetitive ingestive behavior and consummatory ingestive behavior in male rats, respectively.