Serum biochemical values in two inbred strains of Mastomys (Praomys coucha)

Serum samples collected from 119 (72 male and 47 female) mastomys (Praomys coucha) of 2 specific-pathogen-free inbred strains (R14 and R17)were analyz ed for 12 serum biochemical parameters. Sex-related differences (p<0.01) we re noted in alkaline phosphatase and glucose; the both higher in females th an in males. Age-related changes (p<0.01) were observed in total protein, a lbumin, total cholesterol, and alkaline phosphatase, with higher values for the first three parameters in the older group (200-250 days of age) than i n the younger group (90-140 days of age). Four out of 12 parameters showed strain-related differences (p<0.01), consistent with the large amount of ge netic heterogeneity reported in this species. These serum biochemical refer ence values should provide information for the use of mastomys in laborator y research.