Objective: To identify areas requiring the most urgent improvement in
the intensive care unit (ICU) and to accurately determine the positive
predictive value of routine critical care patient monitoring alarms,
as well as the common causes for false-positive alarms. Design: Prospe
ctive, observational study. Setting: A multidisciplinary ICU in a univ
ersity-affiliated children's hospital (excluding children with primary
heart disease). Interventions: The occurrence rate, cause, and approp
riateness of all alarms from tracked monitors were recorded by a train
ed observer and validated by the bedside nurse over a 10-wk period for
a single bedspace at a time. Measurements and Main Results: After 298
monitored hrs, 86% of a total 2,942 alarms were found to be false-pos
itive alarms, while an additional 6% were classified as clinically irr
elevant true alarms. Only 8% of all alarms tracked during the study pe
riod were determined to be true alarms with clinical significance. Ala
rms were also classified according to whether they were clearly associ
ated with a ''patient intervention'' (18%), were clearly not associate
d with a patient intervention (74%), or had unclear association to int
erventions (8%). While 11% of ''nonpatient intervention'' alarms were
clinically significant true alarms, only 2% of ''patient intervention'
' alarms were so. Positive predictive values for the various devices r
anged from <1% for the purse oximeter's heart rate signal to 74% for t
he arterial catheter's mean systemic blood pressure signal during peri
ods free from patient interventions. The pulse oximeter caused false-p
ositive alarms most frequently, with common reasons being bad data for
mat/bad connection and poor contact. Conclusion: Efforts to develop in
telligent monitoring systems have more potential to deliver significan
tly improved patient care by initially targeting especially weak areas
in ICU monitoring, such as pulse oximetry reliability.