Synthesis and reactivity of some Mannich bases. VII. Synthesis of 3-(2-dialkylaminoethyl)-1,2-benzisoxazoles

Authors
Comanita, E Popovici, I Roman, G Robertson, G Comanita, B
Citation
E. Comanita et al., Synthesis and reactivity of some Mannich bases. VII. Synthesis of 3-(2-dialkylaminoethyl)-1,2-benzisoxazoles, HETEROCYCLE, 51(9), 1999, pp. 2139-2146
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
51
Issue
9
Year of publication
1999
Pages
2139 - 2146
Database
ISI
SICI code
0385-5414(19990901)51:9<2139:SAROSM>2.0.ZU;2-2
Abstract
3-(2-Dialkylaminoethyl)-1,2-benzisoxazoles (2) are accessible by direct cyc lization of the corresponding Mannich bases oxime acetates (11) in refluxin g benzene in the presence of anhydrous potassium carbonate. The previously known methods for ring closure to 1,2-benzisoxazole were ineffective for th is class of pharmacologically relevant compounds.