Treatment of central giant cell granuloma of the jaw with calcitonin

Giant cell granuloma of the jaw is a benign lesion that may cause local des truction of bone and displacement of teeth. The common therapy is curettage or resection, which may be associated with loss of teeth and, in younger p atients, loss of dental germs, An alternative treatment has recently been i ntroduced, in which patients receive a daily dose of calcitonin. Four patie nts who have been treated with calcitonin in various concentrations for at least 1 year are reported. in all patients, complete remission of the giant cell granuloma was observed, without signs of recurrence. The working mech anism of calcitonin is discussed, as are length of treatment and optimal do se.