DOSE-DEPENDENT EFFECTS OF YOHIMBINE ON METHADONE-MAINTAINED PATIENTS

Authors
HAMEEDI FA WOODS SW ROSEN MI PEARSALL HR KOSTEN TR
Citation
Fa. Hameedi et al., DOSE-DEPENDENT EFFECTS OF YOHIMBINE ON METHADONE-MAINTAINED PATIENTS, The American journal of drug and alcohol abuse, 23(2), 1997, pp. 327-333
Citations number
13
Categorie Soggetti
Substance Abuse","Psycology, Clinical
Journal title
The American journal of drug and alcohol abuse → ACNP
ISSN journal
00952990
Volume
23
Issue
2
Year of publication
1997
Pages
327 - 333
Database
ISI
SICI code
0095-2990(1997)23:2<327:DEOYOM>2.0.ZU;2-D
Abstract
Twelve methadone-maintained patients were randomized into a controlled crossover study with active and placebo yohimbine 20 mg once a day (n = 4), 5mg three times a day (n = 4) or 10 mg three times a day (n = 4 ) for seven days to evaluate the effect of yohimbine on naloxone preci pitated opiate withdrawal. The yohimbine dose of 10 mg TID was well to lerated and was associated with an average decrease of 30% in precipit ated withdrawal symptoms.