Lack of effect of cimetidine on the pharmacokinetics of sustained-release bupropion

The objective of this study was to assess whether cimetidine affects the ph armacokinetics of sustained-release (SR) bupropion hydrochloride and the ac tive metabolite, hydroxybupropion. This randomized, open-label, two-period crossover study was conducted in 24 healthy volunteers 18 to 45 years of ag e. ANOVA showed that administration of two 150 mg bupropion SR tablets with one 800 mg cimetidine tablet following an overnight fast did not change va lues for AUC(infinity) C-max, t(max), t(1/2) and CL/F (CL/F calculated for bupropion only) for either bupropion or hydroxybupropion as compared with t wo 150 mg bupropion SA tablets alone. In this study, if appears that there is no effect of cimetidine on the pharmacokinetics of bupropion SR. (C) 199 9 the American College of Clinical Pharmacology.