T. Kawakatsu et al., EFFECT OF 3 JAPANESE KAMPO MEDICINES ON PLATELET ACTIVATION BY MONOCLONAL ANTIPLATETLET MEMBRANE GLYCOPROTEIN ANTIBODIES, The American journal of Chinese medicine, 22(1), 1994, pp. 71-76
We studied the effect of three Japanese kampo medicines on platelet ac
tivation by an anti-CD9 monoclonal antibody (NNKY1-19) and an anti-hum
an Fe gamma receptor II monoclonal antibody (NNKY3-2). Sho-saiko-to (T
J-9) and Sairei-to (TJ-114) partially suppressed platelet aggregation
induced by NNKY1-19, while Juzen-taiho-to (TJ-48) suppressed aggregati
on induced by NNKY3-2. TJ-9 and TJ-114 also suppressed collagen-induce
d aggregation, but TJ-48 did not. Flow cytometry showed that the three
medicines did not affect antibody binding to the platelets. Thus, all
three kampo medicines suppressed platelet activation by anti-platelet
glycoprotein antibodies without inhibiting antibody binding.