EFFECT OF COMMIPHORA-MOLMOL (OLEO-GUM-RESIN) ON THE CYTOLOGICAL AND BIOCHEMICAL-CHANGES INDUCED BY CYCLOPHOSPHAMIDE IN MICE

Authors
ALHARBI MM QURESHI S AHMED MM RAFATULLAH S SHAH AH
Citation
Mm. Alharbi et al., EFFECT OF COMMIPHORA-MOLMOL (OLEO-GUM-RESIN) ON THE CYTOLOGICAL AND BIOCHEMICAL-CHANGES INDUCED BY CYCLOPHOSPHAMIDE IN MICE, The American journal of Chinese medicine, 22(1), 1994, pp. 77-82
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
Journal title
The American journal of Chinese medicine → ACNP
ISSN journal
0192415X
Volume
22
Issue
1
Year of publication
1994
Pages
77 - 82
Database
ISI
SICI code
0192-415X(1994)22:1<77:EOC(OT>2.0.ZU;2-4
Abstract
The anticlastogenic and biochemical potentials of Commiphoramolmol wer e studied in Swiss albino mice treated with cyclophosphamide (CP). The C. molmol treatment (125-500 mg/kg) showed no mutagenicity. It caused a highly significant and dose-dependent mitodepressant effect in the femoral cells and reduction of RNA levels in hepatic cells as compared with the control. CP treatment showed significant increase in the fre quency of micronuclei, cytotoxicity and reduction in the contents of n ucleic acids and proteins. Pretreatment with C. molmol could neither a lter the biochemical and cytological effects of CP nor show any additi ve effect of both treatments.