Immunoadsorption in multifocal motor neuropathy

To our knowledge, this is the first reported application of immunoadsorptio n in a patient with multifocal motor neuropathy (MMN). The diagnosis relied on the typical clinical features, markedly increased IgM-GM1 antibodies, m ultiple motor conduction blocks, and motor nerve biopsy. Immunoadsorption w as carried out in seven cycles of two sessions each within 97 days. From th e first therapy, muscle force as well as nerve conduction velocity and cond uction blocks deteriorated continuously. As a consequence, immunoadsorption cannot be recommended as a treatment for MMN.