EXPRESSION OF GST-PI IN GASTRIC-CANCER TISSUES AND PRENEOPLASTIC LESIONS

GST-pi is closely associated with human cancer. With the technique of PAP (peroxidaseantiperoxidase procedure) immunohistochemical staining, we examined GST-pi expression in normal gastric mucosa, preneoplastic lesions and different histological types of gastric cancer. We found GST-pi was almost unexpressed in normal gastric mucosa, but in gastric cancer and preneoplastic lesions (especially dysplastic epithelium) G ST-pi expression was elevated. The staining positive rates with anti-G ST-pi antibody were 64. 6% and 72. 7% respectively. These results indi cated that GST-pi might be a marker for gastric cancer and preneoplast ic lesions, which would play an important role in finding and treating gastric cancer earlier. In addition, that GST-pi expression was relat ed to cell differentiation was also found.