State estimation is an integral part of process monitoring, diagnosis and c
ontrol. Due to the mathematical complexity of nonlinear model, optimal stat
e estimation is much less established in practice. In this work, the variab
le-structure neural network (VSNN) of Tung et al. is employed for nonlinear
state estimation. Similar to the Kalman filter approach, the filter gain i
s adjusted according to the the ratio of noise and error covariance. An alg
orithm is proposed to approximate the error covariance and, subsequently, r
esults in a non-iterative procedure in the filter gain calculation. Moreove
r, when some of the states are not measurable, the VSNN naturally results i
n a RecN-like architecture for the unmeasured states. A chemical reactor ex
ample is used to demonstrate the effectiveness of the VSNN state estimation
scheme. Results show that the variable-structure neural network provides e
ffective state estimation for nonlinear chemical reaction systems. More imp
ortantly, ail the on-line computing can be carried out with standard neural
network software in a non-iterative manner.