Benzodiazepine receptor (BZR) ligands. 5. New 3-alkyloxycarbonyl-, 3-cyclo-alkyloxycarbonyl-, 3-aryloxy-carbonyl derivatives of pyrazolo [5,1-c][1,2,4]benzotriazine 5-oxides: A study on the 3-ester function modification

Authors
Costanzo, A Guerrini, G Ciciani, G Bruni, F Selleri, S Costa, B Martini, C Lucacchini, A Malmberg, PA Ipponi, A
Citation
A. Costanzo et al., Benzodiazepine receptor (BZR) ligands. 5. New 3-alkyloxycarbonyl-, 3-cyclo-alkyloxycarbonyl-, 3-aryloxy-carbonyl derivatives of pyrazolo [5,1-c][1,2,4]benzotriazine 5-oxides: A study on the 3-ester function modification, MED CHEM RE, 9(5), 1999, pp. 322-339
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
MEDICINAL CHEMISTRY RESEARCH
ISSN journal
10542523 → ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
322 - 339
Database
ISI
SICI code
1054-2523(1999)9:5<322:BR(L5N>2.0.ZU;2-C
Abstract
The synthesis of new 3-alkyloxycarbonyl-, 3-cyclo-alkyloxycarbonyl-, 3-aryl oxycarbonyl derivatives of pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their binding affinities at the central benzodiazepine receptor (BZR) are reported. The 3-propynyl ester 10 and the 3-benzyl ester 16, having the bes t affinity values, were chosen for in, vivo testing.