The effect of APOE on dementia is not through atherosclerosis: The Rotterdam Study

Authors
Slooter, AJC Cruts, M Ott, A Bots, ML Witteman, JCM Hofman, A Van Broeckhoven, C Breteler, MMB van Duijn, CM
Citation
Ajc. Slooter et al., The effect of APOE on dementia is not through atherosclerosis: The Rotterdam Study, NEUROLOGY, 53(7), 1999, pp. 1593-1595
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
53
Issue
7
Year of publication
1999
Pages
1593 - 1595
Database
ISI
SICI code
0028-3878(19991022)53:7<1593:TEOAOD>2.0.ZU;2-4
Abstract
The APOE genotype is involved in atherosclerosis, and atherosclerosis incre ases the risk of dementia, in particular among carriers of the APOE-epsilon 4 allele. We studied, in a population-based setting (244 dementia cases; 1 ,002 nondemented controls), whether APOE is associated with dementia throug h atherosclerosis. As neither adjusting nor stratification for atherosclero sis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.