Markers of bone turnover: consideration on their clinical application in osteoporosis

Osteoporosis is a condition in which an imbalance appears between bone reso rption and formation, with bone resorption exceeding formation. However sin ce the rate of bone loss varies significantly from one individual to anothe r resulting in different degrees of osteoporosis, new biochemical technique s to measure products of bone resorption and bone formation have been used in the last years allowing us to evaluate the degree of bone turnover. Bone tissue is constituted of an inorganic component and an organic matrix of c ollagen and noncollagenous proteins. Suitable bone marker should report the formation and degradation of all these constituents, Today markers of bone formation and markers of bone resorption are available. According to recen t literature and personal data assessment of bone metabolism by the specifi c biochemical markers is helpful to select osteoporotic patients with high or low bone turnover and these parameters should be used to evaluate whethe r bone remains sensitive to different therapies.