Acral erythema in children receiving high-dose methotrexate

scant information is available concerning the occurrence and evolution of c hemotherapy-induced acral erythema in children receiving intravenous high-d ose methotrexate (MTX), Among 50 children with acute lymphoblastic leukemia or lymphoblastic lymphoma receiving a total of 203 courses of high-dose MT X (3-8 g/m(2)), 3 cases of acral erythema were observed, Painful erythema o f finger and toe pads was noted in three children 3 days to 2 weeks after M TX infusion, The lesions resolved completely after blister formation and de squamation, These patients subsequently received high-dose MTX therapy with out cutaneous problems, The present work points out that the chemotherapeut ic schedule need not be modified in selected patients who develop acral ery thema following high-dose MTX infusion.