Non-solvent shock agglomeration technology, part 2: Influence of the preparation method on the pharmaceutic-technological properties of ibuprofen

Conventionally produced racemic or optically active ibuprofen (as a final p urification step recrystallization from organic solvent is carried out) has insufficient galenic properties (no free flow, no direct tabletting), Vari ations of the recrystallization process do not result in a significant impr ovement of the bed properties. By using the new "non-solvent shock agglomer ation"-technology it is, however, possible to produce substances with decis ively improved pharmaceutic-technological characteristics. In particular th e flow properties and the grain spectrum as well as the compressibility are optimized. Changes in the processing conditions, e.g. of the stirring inte nsity of the acceptor medium, result in a slight improvement of individual parameters and make it possible to produce special substance qualities.