COMPARISON OF QUANTITATIVE HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHYAND THE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF PARABENS

Authors
THOMASSIN M CAVALLI E GUILLAUME Y GUINCHARD C
Citation
M. Thomassin et al., COMPARISON OF QUANTITATIVE HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHYAND THE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF PARABENS, Journal of pharmaceutical and biomedical analysis, 15(6), 1997, pp. 831-838
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
15
Issue
6
Year of publication
1997
Pages
831 - 838
Database
ISI
SICI code
0731-7085(1997)15:6<831:COQHTC>2.0.ZU;2-5
Abstract
A method is described for the densitometric determination of the p-hyd roxybenzoic esters and p-hydroxybenzoic acid in mixtures or in drugs. This method is compared with the one used in high performance liquid c hromatography (HPLC). The calibration curves were linear in interval 0 .250-3.60 mu mol ml(-1) per 200 nl per spot. The limit of detection an d the relative standard deviation (RSD) are higher than in HPLC (RSD i s 6% in HPTLC, 3% in HPLC; limit of detection about 40 pmol in HPTLC a nd 25 pmol in HPLC) but HPTLC quantitative determination of parabens i n drugs is faster.